Opportunity Information: Apply for PAR 22 137
The National Institutes of Health (NIH) funding opportunity "Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R01-Clinical Trial Not Allowed)" (Funding Opportunity Number: PAR-22-137) supports research projects that use already-collected data from the ABCD Study to answer important questions about child and adolescent health and development. Rather than funding new data collection or clinical trials, this program is set up to help researchers move faster by analyzing a large, publicly available dataset that is already being gathered and shared through the NIMH Data Archive. The overall goal is to increase scientific knowledge about how adolescents develop across multiple domains, including physical and mental health, cognition, substance use, cultural context, and environmental influences, alongside detailed measures of brain structure and function.
A central feature of this opportunity is the ABCD Study itself, which is following youth beginning at ages 9 to 10 and repeatedly assessing them over a 10-year period. Because the study is longitudinal, it allows researchers to examine change over time, identify early predictors of later outcomes, and explore how different biological, psychological, social, and environmental factors interact across adolescence. The dataset is designed to be broad and multidimensional, meaning applicants can propose analyses that connect mental health symptoms with cognitive performance, relate substance use trajectories to brain development, or investigate how family, school, neighborhood, culture, and other contextual variables shape developmental pathways. The FOA is essentially an invitation for investigators to leverage this rich resource to generate new findings more quickly than would be possible by starting new cohorts from scratch.
The award mechanism is an NIH R01 research project grant, and the notice explicitly states "Clinical Trial Not Allowed," which signals that the funded work should focus on secondary data analysis and related research activities rather than prospective interventional studies that meet the NIH definition of a clinical trial. In practical terms, competitive applications will typically center on clear, testable research questions that can be addressed using the ABCD public use data, with rigorous methods, transparent analytic plans, and strong justification for why the proposed analyses matter for understanding adolescent health and development. Since the data are housed in the NIMH Data Archive, projects should be feasible within the structure and content of that repository and aligned with responsible data use and privacy protections associated with secondary analysis of human participant data.
Eligibility for this opportunity is broad and includes many types of domestic organizations and, notably, certain non-U.S. entities as well. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education, where applicable); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility is meant to encourage participation from diverse institutions and communities, including those that are often underrepresented in large-scale research funding.
In terms of administrative details, the opportunity is listed as a discretionary grant under NIH, with activity areas spanning environment and health, and it is associated with multiple CFDA numbers (93.113, 93.242, 93.273, 93.313), reflecting the involvement of NIH institutes and programs that support different aspects of health research. The FOA was created on March 15, 2022, and the original closing date provided is May 7, 2025. The source information does not specify an award ceiling or expected number of awards, which is common in NIH announcements where budgets and award counts can vary depending on scientific merit, available funds, and the scope of proposed projects.
Overall, this grant opportunity is geared toward researchers who can use the ABCD Study public use dataset to produce timely, high-impact insights into adolescent development. The emphasis is on accelerating discovery by taking advantage of an unusually comprehensive, longitudinal, and widely accessible resource. Applicants that are likely to be responsive include those proposing well-powered, methodologically strong analyses that clarify developmental mechanisms, identify risk and protective factors, and contribute to better understanding of adolescent health and mental health trajectories without initiating new clinical trial activities. For background and context on the dataset and study design, the FOA directs applicants to the ABCD Study website at www.abcdstudy.org and to data access and documentation through the NIMH Data Archive.Apply for PAR 22 137
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R01-Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.242, 93.273, 93.313.
- This funding opportunity was created on 2022-03-15.
- Applicants must submit their applications by 2025-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PAR-22-137 about?
PAR-22-137, titled "Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R01-Clinical Trial Not Allowed)," supports research projects that use already-collected ABCD Study data to answer important questions about child and adolescent health and development. The focus is on accelerating discovery through secondary analysis of an existing, large, publicly available dataset rather than starting new studies.
What is the main goal of this opportunity?
The overall goal is to increase scientific knowledge about how adolescents develop over time across multiple domains, including physical and mental health, cognition, substance use, cultural context, and environmental influences, alongside detailed measures of brain structure and function.
What is the ABCD Study, and why is it important for this FOA?
The Adolescent Brain Cognitive Development (ABCD) Study is a longitudinal study following youth beginning at ages 9 to 10 and repeatedly assessing them over a 10-year period. Because it tracks the same participants over time, it enables analyses of developmental change, early predictors of later outcomes, and interactions among biological, psychological, social, and environmental factors across adolescence.
Does this grant fund new data collection?
No. This program is designed to use already-collected ABCD Study data. The intent is to speed up research by analyzing a rich dataset that is already being gathered and shared, rather than funding the creation of new cohorts or new prospective data collection.
Are clinical trials allowed under this FOA?
No. The announcement specifies "Clinical Trial Not Allowed." Funded work should focus on secondary data analysis and related research activities, not prospective interventional studies that meet the NIH definition of a clinical trial.
Where is the ABCD Study data available?
The ABCD Study data are publicly available through the NIMH Data Archive. Applications should be feasible within the structure and content of that repository.
What types of research questions are a good fit for this opportunity?
Projects should propose clear, testable questions that can be answered using the ABCD public use dataset. Examples mentioned in the opportunity include connecting mental health symptoms with cognitive performance, relating substance use trajectories to brain development, and examining how family, school, neighborhood, culture, and other contextual variables shape developmental pathways over time.
What makes the ABCD dataset especially useful for research?
The dataset is described as broad and multidimensional, combining measures of brain structure and function with information on physical and mental health, cognition, substance use, environmental influences, and cultural and contextual factors. Its longitudinal design supports analyzing change over time and identifying early predictors of later outcomes.
What grant mechanism is used for this funding opportunity?
This opportunity uses the NIH R01 research project grant mechanism.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include many domestic organizations and also certain non-U.S. entities. Categories listed include: state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as applicable); for-profit organizations other than small businesses; and small businesses.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The FOA explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA includes non-domestic (non-U.S.) entities (foreign organizations) among eligible applicant categories.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicant categories.
Is this a discretionary grant, and what are the activity areas?
Yes. It is listed as a discretionary grant under NIH, with activity areas spanning environment and health.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.113, 93.242, 93.273, and 93.313.
What is the closing date for this funding opportunity?
The original closing date provided is May 7, 2025.
When was the FOA created?
The FOA was created on March 15, 2022.
Is an award ceiling or number of awards specified?
No. The source information does not specify an award ceiling or the expected number of awards. This is common in NIH announcements where budgets and award counts can vary based on scientific merit, available funds, and the scope of proposed projects.
What should competitive applications emphasize?
Competitive applications will typically center on rigorous methods, transparent analytic plans, strong justification for why the analyses matter for understanding adolescent health and development, and research questions that are feasible using the ABCD public use data available through the NIMH Data Archive.
What does "accelerating the pace" mean in the context of this FOA?
It means producing timely, high-impact findings by leveraging an unusually comprehensive dataset that already exists and is being shared, rather than spending years and significant resources building a new cohort and collecting new longitudinal data from scratch.
Where can applicants learn more about the ABCD Study and the dataset?
The FOA directs applicants to the ABCD Study website at www.abcdstudy.org for background and context on the study design, and to the NIMH Data Archive for data access and documentation.
Does this opportunity address privacy and responsible data use?
Yes. The FOA notes that projects should align with responsible data use and privacy protections associated with secondary analysis of human participant data housed in the NIMH Data Archive.
What kinds of outcomes or insights is NIH hoping to generate through this program?
The opportunity is geared toward findings that clarify developmental mechanisms, identify risk and protective factors, and improve understanding of adolescent health and mental health trajectories, using longitudinal ABCD data and without initiating new clinical trial activities.
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