Opportunity Information: Apply for PA 18 465
Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01, Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity (PA-18-465) that supports research aimed at clarifying how cannabinoids and the broader endocannabinoid system can be leveraged to create more effective, mechanism-based treatments for pain. The central emphasis is on generating rigorous scientific evidence about therapeutic potential and underlying biology, with the goal of moving beyond symptom-focused approaches and toward interventions grounded in clear mechanistic understanding. The announcement is structured around the NIH R01 mechanism, which typically supports substantial, hypothesis-driven research projects, and it allows for clinical trials but does not require them, meaning applicants can propose either preclinical/mechanistic work or human studies depending on what best fits the scientific question.
The scope of projects encouraged under this opportunity focuses on elucidating the roles of cannabinoid-related pathways in pain processing and pain relief, including how these pathways might be targeted to produce safer or more effective analgesic strategies. In practical terms, responsive applications would be expected to investigate the endocannabinoid system in a way that meaningfully informs therapy development, such as identifying actionable targets, clarifying signaling mechanisms, characterizing effects on pain circuits, or providing data that would help translate cannabinoid-related biology into rational treatment approaches. Because the FOA highlights "mechanism-based therapies," it is oriented toward studies that connect biological mechanisms to therapeutic outcomes rather than purely descriptive work.
The award is categorized as a discretionary grant and falls under federal activity areas that include education and health, as well as income security and social services, reflecting the broad societal impact of improved pain treatment options. The opportunity is tied to multiple CFDA numbers (93.213, 93.273, 93.279, 93.393, 93.853, 93.865, 93.866), indicating that multiple NIH institutes or centers may be relevant depending on the specific pain condition, scientific approach, or therapeutic angle being proposed. While the source data provided does not list an award ceiling or expected number of awards, the R01 mechanism generally implies support for well-justified projects with budgets aligned to the scope of the work and NIH policies.
Eligibility is broad and includes many types of U.S. organizations and governmental entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions under those categories); for-profit organizations other than small businesses; small businesses; and other applicant types. The FOA also explicitly emphasizes inclusion of additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations. This wide eligibility reflects an intent to attract diverse scientific perspectives and to support research capacity across many institutional settings, including those serving historically underrepresented communities.
From an administrative standpoint, the opportunity was created on December 6, 2017, and the original closing date listed is September 7, 2018. As with many NIH program announcements, the title and number suggest it was part of a structured set of NIH solicitations focused on pain and translational neuroscience, but applicants would typically need to confirm current submission dates and active status through NIH and Grants.gov resources because older FOAs may be reissued, updated, or superseded. Overall, the opportunity is best understood as an NIH R01 pathway for researchers seeking to deliver clear mechanistic insights and translational traction in the development of cannabinoid- and endocannabinoid-based strategies for pain treatment, with flexibility to include clinical testing when scientifically appropriate.Apply for PA 18 465
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01, Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.279, 93.393, 93.853, 93.865, 93.866.
- This funding opportunity was created on 2017-12-06.
- Applicants must submit their applications by 2018-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR) (R41/R42 Clinical Trial Not Allowed) Apply for PAR 18 515 Funding Number: PAR 18 515 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Biology and Biophysics of Neural Stimulation (R01 - Clinical Trials Optional) Apply for RFA NS 18 018 Funding Number: RFA NS 18 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 - Clinical Trials Not Allowed) Apply for RFA NS 18 014 Funding Number: RFA NS 18 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $225,000 |
| BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR)(R43/R44 Clinical Trial Not Allowed) Apply for PAR 18 501 Funding Number: PAR 18 501 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44) - Clinical Trial Optional Apply for PAR 18 541 Funding Number: PAR 18 541 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 - Clinical Trial Required) Apply for RFA NS 18 021 Funding Number: RFA NS 18 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44 Clinical Trial Required) Apply for RFA NS 18 022 Funding Number: RFA NS 18 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3 - Clinical Trial Required) Apply for RFA NS 18 023 Funding Number: RFA NS 18 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3) - Clinical Trial Optional Apply for PAR 18 546 Funding Number: PAR 18 546 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 18 573 Funding Number: PA 18 573 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required) Apply for PA 18 576 Funding Number: PA 18 576 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: New Concepts and Early - Stage Research for Large - Scale Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed) Apply for RFA EY 18 001 Funding Number: RFA EY 18 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (R01 Clinical Trials Not Allowed) Apply for RFA NS 18 020 Funding Number: RFA NS 18 020 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01-Clinical Trials Not Allowed) Apply for RFA NS 18 019 Funding Number: RFA NS 18 019 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Reducing Stigma to Improve HIV/AIDS Prevention, Treatment and Care in Low and Middle- Income Countries (R21 Clinical Trial Optional) Apply for PAR 18 732 Funding Number: PAR 18 732 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $125,000 |
| Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (R21 Clinical Trial Optional) Apply for PAR 18 745 Funding Number: PAR 18 745 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (R01 Clinical Trial Optional) Apply for PAR 18 747 Funding Number: PAR 18 747 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed) Apply for RFA NS 18 030 Funding Number: RFA NS 18 030 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 19 136 Funding Number: RFA MH 19 136 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 18 814 Funding Number: PAR 18 814 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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