Opportunity Information: Apply for TI 23 010
The Emergency Department Alternatives to Opioids Demonstration Program (ED-ALT) is a discretionary federal grant opportunity from the U.S. Department of Health and Human Services (HHS), administered by the Substance Abuse and Mental Health Services Administration (SAMHSA). The central aim is to help hospitals and emergency departments put practical, workable pain-management approaches in place that reduce reliance on opioid medications. In addition to expanding non-opioid options for acute pain care, the program is designed to lower the chances that patients treated in emergency settings will later experience opioid misuse. A second, closely related focus is improving how emergency care teams identify people who may already be experiencing Opioid Use Disorder (OUD) and ensuring those individuals receive timely intervention and appropriate connections to treatment and support.
At its core, the ED-ALT program supports the development and implementation of clinical pathways, protocols, and services that make non-opioid pain treatments more accessible and more consistently used in emergency and hospital settings. While the opportunity synopsis does not list specific clinical modalities, "alternatives to opioids" in ED contexts commonly refers to multimodal pain management that may include non-opioid medications, non-pharmacologic interventions, and structured clinical decision tools that help clinicians choose safer options when appropriate. The overall intent is not simply to reduce opioid prescribing in a vacuum, but to maintain or improve pain care while also reducing downstream risk, especially for patients who might be vulnerable to developing problematic opioid use after an ED encounter.
The grant also explicitly supports identification and intervention for individuals presenting with OUD. In real-world emergency department workflows, this typically means strengthening screening and assessment processes, building ED capacity to initiate evidence-based responses, and improving referral and linkage systems so that people with OUD do not leave the ED without a clear pathway to follow-up care. The emphasis on intervention indicates the program is meant to move beyond recognition alone and toward active steps that reduce harm and increase engagement with treatment.
From an administrative standpoint, this is a grant (Funding Instrument Type: Grant) in the health funding category, listed under CFDA number 93.788. The opportunity number is TI 23 010, and it was posted on January 5, 2023, with an original application closing date of March 6, 2023. The award ceiling is $500,000 per award, and SAMHSA anticipated making approximately 14 awards. Eligibility is listed as "Others" with additional eligibility details referenced in the full notice (the summary provided does not include that expanded eligibility language), so applicants would normally need to consult the full funding announcement to confirm which types of organizations are permitted to apply and whether any special qualifications or partnerships are required.
Taken together, ED-ALT is positioned as a demonstration-oriented investment in emergency care practice change: helping EDs and hospitals implement non-opioid pain strategies while also strengthening the front-door response to OUD. The program reflects the idea that emergency departments are a critical intervention point, both for safer pain treatment decisions and for rapidly identifying and engaging patients who may need addiction-related services.Apply for TI 23 010
- The Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Emergency Department Alternatives to Opioids Demonstration Program (ED-ALT)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.788.
- This funding opportunity was created on Jan 05, 2023.
- Applicants must submit their applications by Mar 06, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 14 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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| Provision of Voluntary Medical Male Circumcision (VMMC) for HIV Prevention in the Republic of South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0006 Funding Number: CDC RFA GH 23 0006 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Medication-Assisted Treatment – Prescription Drug and Opioid Addiction Apply for TI 23 001 Funding Number: TI 23 001 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $750,000 |
| A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes Apply for CDC RFA DP 23 0020 Funding Number: CDC RFA DP 23 0020 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $3,300,000 |
| Re-envisioning Excellence and Accessibility in Clinic-based HIV Services (“REACH 95”) Activity Apply for 72012123RFA00001 Funding Number: 72012123RFA00001 Agency: Agency for International Development, Ukraine USAID-Kiev Category: Health Funding Amount: $19,000,000 |
| National Asian Language Tobacco Quitline Apply for CDC RFA DP 23 0011 Funding Number: CDC RFA DP 23 0011 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $900,000 |
| Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART) Apply for RFA PS 23 002 Funding Number: RFA PS 23 002 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $450,000 |
| Strengthening Scale Up of HIV Prevention, Care and Treatment Programs in South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0034 Funding Number: CDC RFA GH 23 0034 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Rape Prevention and Education: Assessing Coalition Capacity to Advance Primary Prevention Apply for CDC RFA CE 23 0006 Funding Number: CDC RFA CE 23 0006 Agency: Department of Health and Human Services, Centers for Disease Control - NCIPC Category: Health Funding Amount: $115,641 |
| Comprehensive Systems Integration for Adolescent and Young Adult Health Apply for HRSA 23 079 Funding Number: HRSA 23 079 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $1,514,450 |
| Pediatric Emergency Care Applied Research Network (PECARN) Apply for HRSA 23 073 Funding Number: HRSA 23 073 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: $700,000 |
| Scaling-up Sustainable Voluntary Medical Male Circumcision (VMMC) through Improvements in the Availability, Integration, and Quality of HIV Prevention Services in Zimbabwe under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0017 Funding Number: CDC RFA GH 23 0017 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Sustainable, Innovative, and Agile Community and Facility HIV Prevention, Care and Treatment Services for Epidemic Control among all Populations in Zimbabwe under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0018 Funding Number: CDC RFA GH 23 0018 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening an Integrated Comprehensive Approach for HIV Services for Adolescents and Young People through Determined, Resilient, AIDS-Free Mentored and Safe (DREAMS) Program in Zimbabwe under the President's Emergency Plan for AIDS Relief (PE Apply for CDC RFA GH 23 0019 Funding Number: CDC RFA GH 23 0019 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Strengthening Laboratory Systems that Support Diagnosis, Treatment, Prevention, and Management of HIV/AIDS and Related Public Health Diseases in the Republic of South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH 23 0035 Funding Number: CDC RFA GH 23 0035 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Exploring Preferences for Long-Acting Antiretroviral Therapies (LA-ART) in a Community-Based Sample of Priority Populations Living with HIV Who are Disproportionately Affected Apply for RFA PS 23 003 Funding Number: RFA PS 23 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $333,000 |
| Expanding Rapid Initiation of Antiretroviral Therapy in Non-traditional Settings: Emergency Department Apply for RFA PS 23 005 Funding Number: RFA PS 23 005 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $500,000 |
| Increasing PrEP Use Among Disproportionately Affected Populations in the United States Apply for RFA PS 23 001 Funding Number: RFA PS 23 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $2,000,000 |
| First Responders – Comprehensive Addiction and Recovery Act Apply for TI 23 012 Funding Number: TI 23 012 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $800,000 |
| A Strategic Approach to Advancing Health Equity for Priority Populations with or at Risk for Diabetes—Subject Matter Expertise, Training, and Technical Assistance Apply for CDC RFA DP 23 0021 Funding Number: CDC RFA DP 23 0021 Agency: Department of Health and Human Services, Centers for Disease Control - NCCDPHP Category: Health Funding Amount: $10,000,000 |
| Community Programs for Outreach and Intervention with Youth and Young Adults at Clinical High Risk for Psychosis Apply for SM 23 014 Funding Number: SM 23 014 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $400,000 |
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