Opportunity Information: Apply for RFA RM 17 015
The National Institutes of Health (NIH) offered this funding opportunity to support a dedicated Metabolomics Core for Phase II of the Undiagnosed Diseases Network (UDN). The UDN is a research-focused clinical network designed to help solve rare and difficult-to-diagnose medical cases, and this particular award is aimed at ensuring the network has centralized, high-quality metabolomics capabilities. In practical terms, the Metabolomics Core would be expected to provide specialized metabolic profiling and related analytic support that can help identify biochemical signatures of disease, generate diagnostic leads, and contribute to discovering new mechanisms underlying previously undiagnosed conditions. The award uses the U01 mechanism, which is a cooperative agreement, meaning the NIH typically anticipates substantial programmatic involvement during the project period (for example, coordination requirements, shared milestones, and active collaboration with other UDN components rather than a fully independent, investigator-directed grant).
This announcement is identified as “Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01)” with Funding Opportunity Number RFA-RM-17-015. It falls under the discretionary funding category and the health funding activity category, and it is associated with CFDA number 93.310. The announcement was created on August 15, 2017, and the original application closing date was November 2, 2017. The listing does not provide an award ceiling or the expected number of awards in the provided source text, so those details would normally need to be confirmed by checking the full FOA or NIH’s archived notice.
Eligibility is broad and covers many typical NIH-eligible domestic applicant types, including state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); public housing authorities/Indian housing authorities; and Native American tribal organizations that are not federally recognized tribal governments. It also includes nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education, which are listed separately), for-profit organizations (other than small businesses), and small businesses, plus an “other” category that NIH sometimes uses to capture additional eligible organizational forms. The FOA explicitly notes additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
At the same time, the announcement draws a clear line on foreign eligibility. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic (non-U.S.) entities categorized as foreign institutions are stated as not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, the FOA allows “foreign components” as defined in the NIH Grants Policy Statement. In NIH terms, that usually means a U.S. applicant organization can include certain clearly justified project elements performed outside the U.S. (for example, specific analyses, samples, or collaborations), as long as they are structured as foreign components under NIH policy and meet NIH’s requirements for justification, oversight, and reporting. This setup preserves the requirement that the applicant organization itself be domestic while still allowing limited, policy-compliant international involvement when it adds scientific value.
Overall, this opportunity is best understood as NIH’s effort to maintain a core, network-wide metabolomics resource that can plug into UDN Phase II operations. A successful Metabolomics Core under a cooperative agreement would typically be expected to function as a shared service and scientific partner: receiving and processing biospecimens or data tied to UDN cases, applying metabolomics platforms and quality-controlled workflows, interpreting findings in collaboration with clinicians and other UDN cores/sites, and returning results in a way that supports diagnosis, research discovery, and cross-site consistency. The “core” framing also implies an emphasis on standardization, throughput, data management, and coordination across the network, rather than metabolomics as a stand-alone research project disconnected from UDN case workflows.Apply for RFA RM 17 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2017-08-15.
- Applicants must submit their applications by 2017-11-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The announcement is titled "Metabolomics Core for the Undiagnosed Diseases Network (UDN) Phase II (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-RM-17-015.
Which NIH award mechanism does this opportunity use?
This opportunity uses the U01 mechanism, which is a cooperative agreement.
What does a U01 cooperative agreement generally mean for how the project is run?
A U01 cooperative agreement typically involves substantial programmatic involvement by NIH during the project period. Based on the description provided, this can include coordination requirements, shared milestones, and active collaboration with other UDN components rather than a fully independent, investigator-directed project.
What is the main purpose of this funding opportunity?
The purpose is to support a dedicated, centralized Metabolomics Core for Phase II of the Undiagnosed Diseases Network (UDN), ensuring the network has high-quality metabolomics capabilities that are consistent across sites.
What is the Undiagnosed Diseases Network (UDN) in this context?
The UDN is described as a research-focused clinical network designed to help solve rare and difficult-to-diagnose medical cases.
What is a "Metabolomics Core" expected to do under this opportunity?
The Metabolomics Core is expected to provide specialized metabolic profiling and related analytic support for UDN cases. This includes identifying biochemical signatures of disease, generating diagnostic leads, and contributing to discovery of new mechanisms underlying previously undiagnosed conditions.
How does the "core" model shape what NIH is looking for?
The "core" framing implies a shared, network-wide resource that emphasizes standardization, throughput, data management, and coordination across the UDN. It is positioned as a service and scientific partner integrated into UDN workflows, rather than a stand-alone metabolomics research project operating independently of UDN case needs.
What kinds of activities are implied by a network-wide metabolomics resource?
Based on the provided description, expected activities typically include receiving and processing biospecimens or data tied to UDN cases, applying metabolomics platforms with quality-controlled workflows, interpreting findings in collaboration with clinicians and other UDN cores/sites, and returning results in a way that supports diagnosis, research discovery, and cross-site consistency.
Is this opportunity considered discretionary funding and what is the funding activity area?
Yes. It is described as falling under the discretionary funding category and the health funding activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.310.
When was the announcement created?
The listing states the announcement was created on August 15, 2017.
What was the original application closing date?
The original application closing date listed is November 2, 2017.
Does the provided information specify an award ceiling or the expected number of awards?
No. The provided source text does not include an award ceiling or the expected number of awards. Those details would typically need to be confirmed by reviewing the full FOA or NIH archived materials.
What types of organizations are eligible to apply (broadly)?
Eligibility is described as broad and includes many domestic applicant types commonly eligible for NIH funding, including various government entities, institutions of higher education (public and private), tribal entities, nonprofits, and for-profit organizations, including small businesses.
Which government entities are listed as eligible applicants?
Eligible government applicant types listed include state governments; county governments; city or township governments; special district governments; and independent school districts.
Are institutions of higher education eligible?
Yes. Eligible applicant types include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list includes Native American tribal governments (federally recognized) and Native American tribal organizations that are not federally recognized tribal governments.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.
Are nonprofit organizations eligible?
Yes. Nonprofits with or without 501(c)(3) status are included, as long as they are not institutions of higher education (which are listed separately).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations (other than small businesses), and it also separately includes small businesses.
Does the opportunity mention any additional eligible applicant types beyond the standard categories?
Yes. Additional eligible applicant types explicitly noted include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply directly?
No. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic entities categorized as foreign institutions are stated as not eligible to apply.
Can a U.S. organization apply if it has non-domestic components?
No. The announcement states that non-domestic components of U.S. organizations are not eligible to apply.
Does the opportunity allow any international involvement at all?
Yes, but in a limited, policy-defined way. While foreign organizations cannot apply and non-domestic components are not eligible to apply, the FOA allows "foreign components" as defined in the NIH Grants Policy Statement.
What does "foreign components" mean in practical terms based on the description provided?
In NIH terms (as summarized in the provided text), a domestic U.S. applicant organization may include certain justified project elements performed outside the U.S., such as specific analyses, samples, or collaborations, as long as they are structured as foreign components under NIH policy and meet NIH requirements for justification, oversight, and reporting.
How should applicants think about the Metabolomics Core role within UDN Phase II?
The opportunity is presented as NIH's effort to maintain a centralized, network-wide metabolomics resource that integrates into UDN Phase II operations. The core is expected to "plug into" UDN workflows and support diagnosis and research discovery across the network.
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